Publications

Latest Publications

Selecting aminoacyl-tRNA synthetase/tRNA pairs for efficient genetic encoding of noncanonical amino acids into proteins.

Alexander ND, Gangarde YM, Bednar RM, Karplus PA, Cooley RB, Mehl RA. Nat Protoc. 2025

Tuning Encodable Tetrazine Chemistry for Site-Specific Protein Bioorthogonal Ligations.

Jana S, Eddins AJ, Gangarde YM, Karplus PA, Mehl RA. Angew Chem Int Ed Engl. 2025

Quantitative Protein Labeling in Live Cells by Controlling the Redox State of Encoded Tetrazines.

Eddins AJ, Gangarde YM, Singh A, Jana S, Zheng Y, Alexander ND, Reitsma JM, Cooley RB, Karplus PA, Mehl RA. J Am Chem Soc. 2025

In-Cell Approach to Evaluate E3 Ligases for Use in Targeted Protein Degradation.

Zheng Y, Singh A, Niu Z, Marin V, Young J, Richardson P, Hemshorn ML, Cooley RB, Karplus PA, Puvar K, Warder SE, Vasudevan A, Reitsma JM, Mehl RA. J Am Chem Soc. 2025

Tetrazine Amino Acid Encoding for Rapid and Complete Protein Bioconjugation.

Eddins AJ, Pung AH, Cooley RB, Mehl RA. Bio Protoc. 2024

Genetic Encoding of Phosphorylated Amino Acids into Proteins.

Allen MC, Karplus PA, Mehl RA, Cooley RB. Chem Rev. 2024